Biologics are currently the most targeted form of therapy offered as they are made from actual human DNA to be used in the treatment of various conditions, targeting a specific immune system response. Essentially, biologics are genetically produced drugs that are made from living organisms or cells developed in a lab.
The body comprises of a particular form of protein known as an interleukin that assists the immune system in warding off infection and disease. In people with conditions such as atopic dermatitis (eczema), an overreaction of the immune prompts some interleukins to cause inflammation. This inflammation then results in the patches of red, dry, and itchy skin with which most eczema types present themselves.
Biologics work by preventing interleukin proteins from attaching to their cell receptors, hindering the immune system reaction responsible for the symptoms of eczema. Biologics regulate the immune system to reduce the inflammation it incites, leading to fewer eczema symptoms.
Dupixent Dupilumab Eczema Treatment
Dupixent or dupilumab became the first FDA-approved biologic drug to treat individuals with moderate to severe eczema who have had no success with standard topical therapies.
Dupixent targets two interleukins–IL-4 and IL-13–associated with eczema by barring them from getting attached to their cell receptors. In turn, the drug hinders the overreaction of the immune system, reducing the intensity of inflammation and easing eczema symptoms.
In clinical studies consisting of over 2100 patients with moderate-to-severe eczema, the symptoms of over 50% of the participants improved by 75% while on Dupixent over the course of 16 weeks. Additionally, patients reported a dramatic decrease in itching after 16 weeks on the drug.
Given that most eczema types, including atopic dermatitis, are chronic, it is recommended that individuals continue taking Dupixent to benefit from the medication in the long run. Following two 600-mg doses at the beginning of the treatment, a 300-mg dose of Dupixent is taken intravenously every other week.
Are there any side effects?
Just as with before going on any other medicine, make sure to see your physician to discuss whether a biologic drug such as Dupixent is a fit for your situation. The most common side effects associated with Dupixent include pink eye, cold sores, and scar tissue on sites of injection.
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