IBRANCE, or palbociclib, is a drug approved for the treatment of advanced stages of breast cancer. It can treat metastatic, hormone-receptor-positive, or HER2-negative breast cancers when used with the hormone therapy Faslodex (fulvestrant). Only post-menopausal women whose breast cancer has continued to grow after hormone therapy can use this combination of IBRANCE palbociclib breast cancer treatments.
Femara (letrozole) is also approved by the US Food and Drug Administration (FDA) for the treatment of advanced stages of metastatic, hormone-receptor-positive, HER2-negative breast cancer. It is also used in combination with IBRANCE-palbociclib. This combination should only be used in post-menopausal women if their breast cancer hasn’t already been treated with hormonal therapy.
Essentially, IBRANCE-palbociclib helps to stop the division and growth of cancer cells.
IBRANCE prescribed with Femara, which is available in the form of a pill, is a 28-day cycle. During the first 21 days, IBRANCE and Femara are taken at the same time with food. In the last seven days, only Femara is taken.
If IBRANCE is taken with Faslodex, you should take IBRANCE pills at the same time each day for 21 days and then stop taking them for seven days. You will receive an injection of Faslodex every two weeks for the first three injections. After that, you will only receive one injection per month.
Do not take St. John’s Wort or any medication that contain a CYP3A inducer. They will decrease the effects of IBRANCE.
Do not take any medication with CYP3A inhibitor, eat grapefruit or pomegranate, or drink grapefruit juice or pomegranate juice. They will increase the effects of IBRANCE.
Side effects of using IBRANCE-palbociclib include anemia, fatigue, nausea, diarrhea, vomiting, lack of appetite, hair thinning or hair loss, or neuropathy.
You may also experience the side effects of any other drug that you have been prescribed with IBRANCE-palbociclib.
Some serious side effects also include blood clots, infections and a low white blood cell count.
See a professional doctor or oncologist to discuss which treatment would work best for you and your condition. There is no guarantee that these treatments will work well for everyone. It is important to find a treatment that is targeted towards your specific case of breast cancer.
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